陈雪帆,施咨含.塑料型喷雾剂泵目标元素测定方法的研究[J].包装工程,2023,44(21):267-272.
CHEN Xue-fan,SHI Zi-han.Determination Method of Elements in Plastic Spray Pump[J].Packaging Engineering,2023,44(21):267-272. |
| 塑料型喷雾剂泵目标元素测定方法的研究 |
| Determination Method of Elements in Plastic Spray Pump |
| 投稿时间：2023-04-23 |
| DOI：10.19554/j.cnki.1001-3563.2023.21.033 |
| 中文关键词: 喷雾剂泵 电感耦合等离子质谱 微波消解法 元素测定 |
| 英文关键词: spray pump inductively coupled plasma-mass spectrometry microwave digestion method element analysis |
| 基金项目:浙江省药品接触材料质量控制研究重点实验室开放基金资助项目(2014E10006) |
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| 中文摘要: |
| 目的 建立塑料型喷雾剂泵中12种元素的电感耦合等离子质谱(ICP-MS)测定方法，并用于测定盐酸羟甲唑啉喷雾剂中的元素含量。方法 采用微波消解法进行样品前处理，使用ICP-MS法测定塑料型喷雾剂泵中硼、铝、钛、铬、锰、铁、锌、镍、砷、钼、镉、铅等12种元素含量。结果 每个元素在0~500 ng/mL浓度范围内线性良好，相关系数r均大于0.99，检测限为0.02~1.71 µg/kg，各元素的加标回收率为92.62%~113.82%，相对标准偏差(RSD)为0.64%~3.41%。采用本方法测定盐酸羟甲唑啉喷雾剂，研究在加速条件下喷雾剂中元素的含量迁移变化，结果为各元素含量均未超过浓度限度。结论 本方法前处理简便、方法准确、灵敏度较高，能够高效快速地测定塑料型喷雾剂泵中元素的含量。 |
| 英文摘要: |
| The work aims to establish an ICP-MS method to detect 12 elements in plastic spray pump, and determine the contents of elements in hydroxymethazoline hydrochloride spray.The method of microwave digestion was used for sample pretreatment, and 12 elements including boron, aluminum, titanium, chromium, manganese, iron, zinc, nickel, arsenic, molybdenum, cadmium and lead in plastic spray pump were tested by ICP-MS. For each element, there was a favorable linearity in the range of 0-500 ng/mLwith the correlation coefficients r>0.99. The detection limit of this method was 0.02-1.71 µg/kg, the rate of recovery was 92.62%-113.82% and the relative standard deviation (RSD) was 0.64%-3.41%. At the same time, with hydroxymethazoline hydrochloride spray as an example, the content migration of elements in the spray was studied under the condition of acceleration, and the results showed that all elements did not exceed the concentration limit. This method established in this work is convenient for sample pretreatment, accurate and highly sensitive and can determine the contents of 12 elements in plastic spray pump rapidly and efficiently. |
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